Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 3.272


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_748152330.775.5e-04Click!
FOSL1chr11_-_654244340.533.3e-02Click!
JUNBchr19_+_12763295,
chr19_+_12763285		0.486.3e-02Click!
FOSBchr19_+_506630890.467.3e-02Click!
JUNDchr19_-_18253048-0.391.4e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_13240868 9.206 NM_001423
 EMP1
epithelial membrane protein 1
chr12_+_13240987 8.057 EMP1
epithelial membrane protein 1
chr1_+_181421984 7.346 LAMC2
laminin, gamma 2
chr18_+_19706979 6.896 NM_000227
NM_001127718
 LAMA3

laminin, alpha 3

chr11_-_65860450 6.435 NM_004292
 RIN1
Ras and Rab interactor 1
chr1_+_181421796 5.974 NM_005562
NM_018891
 LAMC2

laminin, gamma 2

chr17_-_36996611 5.023 NM_000526
 KRT14
keratin 14
chr1_+_181422016 4.612 LAMC2
laminin, gamma 2
chr3_+_30622905 4.569 NM_001024847
NM_003242
 TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr1_+_154351082 4.375 NM_005572
NM_170707
NM_170708
 LMNA


lamin A/C


chr3_-_48576204 4.000 NM_033199
 UCN2
urocortin 2
chr11_+_101488380 3.930 NM_001195045
 YAP1
Yes-associated protein 1
chr1_-_151788341 3.829 NM_002960
 S100A3
S100 calcium binding protein A3
chr14_-_104507862 3.812 AHNAK2
AHNAK nucleoprotein 2
chr3_-_152517204 3.761 NM_023915
 GPR87
G protein-coupled receptor 87
chr9_-_129381086 3.723 NM_001035534
 FAM129B
family with sequence similarity 129, member B
chr10_-_88720908 3.620 LOC100133190
hypothetical LOC100133190
chr6_+_83129641 3.604 NM_006670
 TPBG
trophoblast glycoprotein
chr1_-_94779727 3.559 NM_001178096
NM_001993
 F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_207891264 3.417 NM_001017402
 LAMB3
laminin, beta 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
8.85 6.32e-03 GO:0031581 hemidesmosome assembly
4.97 3.58e-02 GO:0032963 collagen metabolic process
2.49 1.69e-03 GO:0008544 epidermis development
1.74 1.59e-02 GO:0042060 wound healing
1.68 9.70e-04 GO:0009888 tissue development
1.59 1.46e-02 GO:0009611 response to wounding
1.30 1.19e-02 GO:0048731 system development
1.28 5.27e-03 GO:0007165 signal transduction
1.28 1.33e-02 GO:0048856 anatomical structure development
1.25 1.93e-02 GO:0023052 signaling
1.23 3.86e-02 GO:0051716 cellular response to stimulus
1.19 5.65e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
11.13 4.65e-02 GO:0034992 microtubule organizing center attachment site
11.13 4.65e-02 GO:0034993 SUN-KASH complex
6.62 2.25e-04 GO:0001533 cornified envelope
2.96 1.63e-02 GO:0045095 keratin filament
2.71 5.75e-03 GO:0044420 extracellular matrix part
2.67 1.08e-04 GO:0005882 intermediate filament
2.64 8.83e-03 GO:0030016 myofibril
2.49 2.25e-02 GO:0043292 contractile fiber
2.38 1.03e-03 GO:0045111 intermediate filament cytoskeleton
2.10 5.07e-04 GO:0005578 proteinaceous extracellular matrix
1.97 9.99e-04 GO:0031012 extracellular matrix
1.81 1.70e-04 GO:0030054 cell junction
1.62 4.31e-05 GO:0044430 cytoskeletal part
1.57 4.96e-04 GO:0044421 extracellular region part
1.52 1.84e-05 GO:0005856 cytoskeleton
1.39 3.02e-04 GO:0005576 extracellular region
1.30 2.29e-02 GO:0044459 plasma membrane part
1.27 6.64e-05 GO:0005886 plasma membrane
1.26 7.58e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.65 1.10e-03 GO:0004866 endopeptidase inhibitor activity
2.60 1.06e-03 GO:0030414 peptidase inhibitor activity
2.55 2.48e-03 GO:0061135 endopeptidase regulator activity
2.26 1.38e-02 GO:0061134 peptidase regulator activity