Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 3.272


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_748152330.775.5e-04Click!
FOSL1chr11_-_654244340.533.3e-02Click!
JUNBchr19_+_12763295,
chr19_+_12763285
0.486.3e-02Click!
FOSBchr19_+_506630890.467.3e-02Click!
JUNDchr19_-_18253048-0.391.4e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13240868 9.206 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240987 8.057 EMP1
epithelial membrane protein 1
chr1_+_181421984 7.346 LAMC2
laminin, gamma 2
chr18_+_19706979 6.896 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr11_-_65860450 6.435 NM_004292
RIN1
Ras and Rab interactor 1
chr1_+_181421796 5.974 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr17_-_36996611 5.023 NM_000526
KRT14
keratin 14
chr1_+_181422016 4.612 LAMC2
laminin, gamma 2
chr3_+_30622905 4.569 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr1_+_154351082 4.375 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr3_-_48576204 4.000 NM_033199
UCN2
urocortin 2
chr11_+_101488380 3.930 NM_001195045
YAP1
Yes-associated protein 1
chr1_-_151788341 3.829 NM_002960
S100A3
S100 calcium binding protein A3
chr14_-_104507862 3.812 AHNAK2
AHNAK nucleoprotein 2
chr3_-_152517204 3.761 NM_023915
GPR87
G protein-coupled receptor 87
chr9_-_129381086 3.723 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr10_-_88720908 3.620 LOC100133190
hypothetical LOC100133190
chr6_+_83129641 3.604 NM_006670
TPBG
trophoblast glycoprotein
chr1_-_94779727 3.559 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_207891264 3.417 NM_001017402
LAMB3
laminin, beta 3
chr3_-_48607596 3.319 NM_000094
COL7A1
collagen, type VII, alpha 1
chr5_+_140848905 3.308 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr12_+_76749199 3.246 NM_014903
NAV3
neuron navigator 3
chr3_+_30623376 3.184 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr18_+_59295123 3.160 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr1_+_34993234 3.113 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr12_+_13240983 3.080 EMP1
epithelial membrane protein 1
chr19_-_56215084 3.049 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr6_-_152744143 3.046 SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_47774247 3.020 NM_153838
GPR115
G protein-coupled receptor 115
chr2_+_28469275 3.013 NM_005253
FOSL2
FOS-like antigen 2
chr7_+_116099648 3.009 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr16_+_56219802 2.996 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr5_+_150000394 2.972 NM_001109974
NM_007286
SYNPO

synaptopodin

chr18_+_59593591 2.969 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr10_+_118177371 2.945 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr17_-_37022465 2.895 NM_005557
KRT16
keratin 16
chrX_+_99786044 2.888 SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_56445653 2.842 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr6_-_169392771 2.793


chr15_-_38417564 2.735 C15orf52
chromosome 15 open reading frame 52
chr7_-_42243142 2.706 NM_000168
GLI3
GLI family zinc finger 3
chr4_+_169989680 2.641 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr13_-_109236897 2.633 NM_003749
IRS2
insulin receptor substrate 2
chr17_-_7962531 2.631 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr10_+_24795446 2.614 KIAA1217
KIAA1217
chr3_+_11153778 2.603 NM_001098213
HRH1
histamine receptor H1
chrX_+_149364377 2.592 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr4_-_115120251 2.581 NM_024590
ARSJ
arylsulfatase family, member J
chr12_-_51173238 2.575 NM_005554
KRT6A
keratin 6A
chr19_+_43572679 2.558 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chrX_+_99785818 2.525 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr5_-_141041982 2.515 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr17_-_24068759 2.487 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr13_-_37070862 2.431 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr20_-_1257782 2.429 SDCBP2
syndecan binding protein (syntenin) 2
chr12_-_105057940 2.419 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr5_+_145297490 2.414 SH3RF2
SH3 domain containing ring finger 2
chr5_-_141041933 2.409 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr6_-_152744022 2.404 SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_+_176807931 2.349 NM_001174102
PRR7
proline rich 7 (synaptic)
chr16_-_2848106 2.341 NM_022119
PRSS22
protease, serine, 22
chr20_+_19903778 2.341 RIN2
Ras and Rab interactor 2
chr9_+_123369219 2.334 NM_032552
DAB2IP
DAB2 interacting protein
chr3_-_150578207 2.331 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr7_-_42243318 2.298 GLI3
GLI family zinc finger 3
chr3_+_57069508 2.270 NM_181727
SPATA12
spermatogenesis associated 12
chr17_-_24069299 2.262 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr3_-_150578103 2.261 TM4SF1
transmembrane 4 L six family member 1
chr1_+_154351162 2.258 LMNA
lamin A/C
chr3_-_150578148 2.218 TM4SF1
transmembrane 4 L six family member 1
chr17_+_71229151 2.180 ITGB4
integrin, beta 4
chr17_-_37034288 2.179 NM_000422
KRT17
keratin 17
chr2_+_28469199 2.162 FOSL2
FOS-like antigen 2
chr5_+_145296313 2.148 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr16_-_46823682 2.145 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr5_+_35892747 2.143 NM_002185
IL7R
interleukin 7 receptor
chr11_+_12265022 2.126 NM_032867
MICALCL
MICAL C-terminal like
chr4_+_81325447 2.125 NM_020226
PRDM8
PR domain containing 8
chr17_+_71229110 2.119 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr18_+_59705918 2.113 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr11_-_128399218 2.080 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr19_+_7859380 2.075 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr11_-_117640196 2.073 MPZL2
myelin protein zero-like 2
chr17_+_21131940 2.072 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr11_-_66898223 2.049 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr10_+_24795465 2.048 KIAA1217
KIAA1217
chr9_+_5500544 2.041 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr7_+_48094750 2.038 NM_181597
UPP1
uridine phosphorylase 1
chr22_-_28972683 2.036 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr3_-_188936941 2.035 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr11_+_35154775 1.991 CD44
CD44 molecule (Indian blood group)
chr14_-_22515725 1.988 JUB
jub, ajuba homolog (Xenopus laevis)
chr15_+_38319326 1.985 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_-_6298284 1.963 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr21_-_35343331 1.956 RUNX1
runt-related transcription factor 1
chr17_+_71229191 1.947 ITGB4
integrin, beta 4
chr15_-_68781662 1.923 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_+_696607 1.919 EPS8L2
EPS8-like 2
chr6_+_31190505 1.910 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr17_-_36928604 1.894 NM_002275
KRT15
keratin 15
chr2_+_28469172 1.894 FOSL2
FOS-like antigen 2
chr6_+_45404031 1.892 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr14_+_51025604 1.861 NM_001042481
FRMD6
FERM domain containing 6
chr11_-_119499188 1.858 TRIM29
tripartite motif containing 29
chr13_+_77007809 1.851 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr21_-_35343456 1.842 NM_001754
RUNX1
runt-related transcription factor 1
chr5_-_1935764 1.836 NM_016358
IRX4
iroquois homeobox 4
chr14_+_95792299 1.836 NM_000710
BDKRB1
bradykinin receptor B1
chr2_-_85494664 1.821 CAPG
capping protein (actin filament), gelsolin-like
chr2_+_233605625 1.812 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr11_+_384199 1.795 NM_007183
PKP3
plakophilin 3
chr7_-_1465487 1.793 MICALL2
MICAL-like 2
chr1_+_154351200 1.791 LMNA
lamin A/C
chr6_+_12398514 1.777 NM_001168319
NM_001955
EDN1

endothelin 1

chr2_-_73170290 1.772 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr8_+_32623792 1.769 NM_013959
NRG1
neuregulin 1
chr11_+_384238 1.769 PKP3
plakophilin 3
chr9_-_116920232 1.766 NM_002160
TNC
tenascin C
chr1_-_115682374 1.754 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr21_-_35343448 1.740 RUNX1
runt-related transcription factor 1
chr9_+_131974506 1.729 NM_014286
NCS1
neuronal calcium sensor 1
chr1_+_151147646 1.722 NM_005547
IVL
involucrin
chr1_-_150564302 1.697 NM_002016
FLG
filaggrin
chr11_-_102174102 1.696 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr21_-_35181956 1.677 RUNX1
runt-related transcription factor 1
chr19_-_18912112 1.677 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr6_+_121798443 1.653 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr3_+_189413414 1.642 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_-_102174032 1.642 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr8_+_120289735 1.636 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_-_177378801 1.615 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr5_+_73145098 1.613 RGNEF
190 kDa guanine nucleotide exchange factor
chr1_-_151280201 1.609 NM_006945
SPRR2D
small proline-rich protein 2D
chr21_+_46226072 1.604 NM_001848
COL6A1
collagen, type VI, alpha 1
chr19_-_43955984 1.604 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_+_696103 1.599 NM_022772
EPS8L2
EPS8-like 2
chr12_-_46439127 1.598 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr3_-_31997738 1.594 OSBPL10
oxysterol binding protein-like 10
chr3_-_31998241 1.593 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr2_-_166359016 1.590 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chrX_-_10761729 1.571 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_134751398 1.561 NM_001083909
GPR123
G protein-coupled receptor 123
chr20_+_33223434 1.533 NM_006404
PROCR
protein C receptor, endothelial
chr2_+_113591940 1.531 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr8_+_22900863 1.530 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr2_-_85494639 1.519 CAPG
capping protein (actin filament), gelsolin-like
chr11_+_47386621 1.519 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr11_-_8695974 1.507 ST5
suppression of tumorigenicity 5
chr11_+_35596310 1.503 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr9_-_109291866 1.480 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr6_+_41712907 1.479 MDFI
MyoD family inhibitor
chr2_-_18634257 1.469 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr11_+_20005704 1.458 NAV2
neuron navigator 2
chr6_-_116799548 1.454 LOC100287467
hypothetical LOC100287467
chr20_+_44070946 1.450 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_+_15128882 1.449 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr19_-_48661563 1.448 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr2_+_220200530 1.439 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr15_+_84021271 1.419 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr6_-_138470160 1.418 NM_022121
PERP
PERP, TP53 apoptosis effector
chr18_+_50646616 1.413 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr16_+_55199978 1.410 NM_005953
MT2A
metallothionein 2A
chr21_-_35343065 1.409 RUNX1
runt-related transcription factor 1
chr18_+_59788242 1.394 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr10_+_102782151 1.392 SFXN3
sideroflexin 3
chr9_-_34652629 1.389 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr21_-_35343500 1.379 RUNX1
runt-related transcription factor 1
chr19_+_49866563 1.357 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr5_+_36642424 1.353 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_46438447 1.348 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chrX_+_106030049 1.336 NM_001171092
CLDN2
claudin 2
chr1_-_33139425 1.325 NM_033504
TMEM54
transmembrane protein 54
chr15_+_38318528 1.319 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr16_+_88515917 1.317 NM_001197181
TUBB3
tubulin, beta 3
chr11_-_123353607 1.315 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr11_+_55335418 1.306 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr5_+_52812236 1.301 NM_006350
NM_013409
FST

follistatin

chr1_-_84237316 1.298 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr7_+_28692122 1.297 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr1_+_27062215 1.294 NM_006142
SFN
stratifin
chr11_-_47164001 1.293 NM_001184975
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr2_-_142605010 1.287 LRP1B
low density lipoprotein receptor-related protein 1B
chr6_+_74462654 1.280 CD109
CD109 molecule
chr10_-_30064600 1.263 NM_003174
SVIL
supervillin
chr10_-_118491971 1.258 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr1_+_17507276 1.251 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr11_-_117640166 1.249 MPZL2
myelin protein zero-like 2
chr11_+_47386707 1.245 SLC39A13
solute carrier family 39 (zinc transporter), member 13
chr10_-_93382837 1.240 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr1_+_35019376 1.239 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr18_+_54039818 1.221 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_65447267 1.219 SPRED2
sprouty-related, EVH1 domain containing 2
chr15_-_53996597 1.213 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr1_-_153272859 1.211 NM_144622
DCST2
DC-STAMP domain containing 2
chr21_-_26465005 1.206 NM_000484
NM_001136129
NM_001136130
NM_201413
NM_201414
APP




amyloid beta (A4) precursor protein




chr21_-_26464931 1.203 APP
amyloid beta (A4) precursor protein
chr4_+_108965167 1.199 NM_001136258
SGMS2
sphingomyelin synthase 2
chr12_-_54646061 1.196 NM_006928
PMEL
premelanosome protein
chr17_-_3408038 1.196 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.68 9.70e-04 GO:0009888 tissue development
2.49 1.69e-03 GO:0008544 epidermis development
1.28 5.27e-03 GO:0007165 signal transduction
1.19 5.65e-03 GO:0050896 response to stimulus
8.85 6.32e-03 GO:0031581 hemidesmosome assembly
1.30 1.19e-02 GO:0048731 system development
1.28 1.33e-02 GO:0048856 anatomical structure development
1.59 1.46e-02 GO:0009611 response to wounding
1.74 1.59e-02 GO:0042060 wound healing
1.25 1.93e-02 GO:0023052 signaling
4.97 3.58e-02 GO:0032963 collagen metabolic process
1.23 3.86e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.52 1.84e-05 GO:0005856 cytoskeleton
1.62 4.31e-05 GO:0044430 cytoskeletal part
1.27 6.64e-05 GO:0005886 plasma membrane
1.26 7.58e-05 GO:0071944 cell periphery
2.67 1.08e-04 GO:0005882 intermediate filament
1.81 1.70e-04 GO:0030054 cell junction
6.62 2.25e-04 GO:0001533 cornified envelope
1.39 3.02e-04 GO:0005576 extracellular region
1.57 4.96e-04 GO:0044421 extracellular region part
2.10 5.07e-04 GO:0005578 proteinaceous extracellular matrix
1.97 9.99e-04 GO:0031012 extracellular matrix
2.38 1.03e-03 GO:0045111 intermediate filament cytoskeleton
2.71 5.75e-03 GO:0044420 extracellular matrix part
2.64 8.83e-03 GO:0030016 myofibril
2.96 1.63e-02 GO:0045095 keratin filament
2.49 2.25e-02 GO:0043292 contractile fiber
1.30 2.29e-02 GO:0044459 plasma membrane part
11.13 4.65e-02 GO:0034992 microtubule organizing center attachment site
11.13 4.65e-02 GO:0034993 SUN-KASH complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.60 1.06e-03 GO:0030414 peptidase inhibitor activity
2.65 1.10e-03 GO:0004866 endopeptidase inhibitor activity
2.55 2.48e-03 GO:0061135 endopeptidase regulator activity
2.26 1.38e-02 GO:0061134 peptidase regulator activity